Here we conduct the first direct metric examination of two early regional manifestations of microlithic industries – the Howiesons Poort of southern Africa (c. 65–60 ka) and the Microlithic industry of South Asia (c. 38–12 ka). Inter-regional comparative analysis of microlithic industries is rare, but can contribute much to our understanding of technological systems in the past. Metric and qualitative variables were recorded on cores, debitage, and tools from Rose Cottage Cave and Umhlatuzana, South Africa, and Batadomba-lena, Sri Lanka, with the aim of conducting a first-stage technological assessment of the degree of technological homogeneity and diversity within these rich microlithic assemblages. The lithic methodology employed here uses the full range of lithic by-products, as opposed to an approach based on tool typology alone. Preliminary analyses reveal areas of significant variation in inter-regional technological strategies. These include differences in blade production and blank selection, variation in microlith typology and morphology, disparate quartz reduction processes designed to produce similar tool types, varying degrees of utilisation of bipolar technology, and the existence of distinct reduction trajectories within sites. The examination of the diversity of microlithic assemblages through the use of detailed technological attribute analyses demonstrates a useful alternative methodology for the way we examine behavioural variability, and is a first step towards a thorough assessment of the place of microliths in models of human dispersals.