This communication study aims to provide evidence on how Sentinel sensors and Copernicus Programme’s contributing missions can support heritage endangered by natural hazards. The recent catastrophic floods of 2022 in Pakistan, mainly in the Indus Valley, threatened one of the most iconic sites within the country; thus, the UNESCO World Heritage Site of Mohenjo-Daro was selected here as a case study. Even if the main area of the site was not directly affected by the floods but rather by the heavy rains, its landscape suffered profound damage. This study aims to report a combined remote-sensing methodology for a rapid assessment of the flooded areas around the site. By using Sentinel-1 radar data in combination with mid-resolution Sentinel-2 data and Planet Lab images, it was possible to accurately map the affected areas near the site. This approach can be used to better understand the extent of the affected areas and build a better recovery strategy. A near-real-time satellite-based investigation and observations combining various sensors and resolutions (Sentinel 1 and 2 images, as well as Planet Lab images) can provide valuable insights for local heritage managers.