As urban centres of agglomeration expand and compete for investment, new demands may arise for additional housing, infrastructure, and services. Failure to meet these demands imposes costs on firms and workers, stifles expansion, and potentially compromises the long-run economic competitiveness of the growth area. Drawing on evidence from Germany (Munich), Sweden (Stockholm), and the UK (Cambridge) this paper examines the organisational and political challenges of growth facilitation in the context of post-Keynesian political and economic restructuring. Particular emphasis is placed on tensions arising from changes in the form and function of European state social regulation. These tensions are not simply a matter of neoliberal regulatory deficit but reflect broader societal cleavages in relation to the uneven spatial impact of local economic growth. Deploying the concept of territorial structures of growth facilitation provides a conceptual framework for taking forward research on the relationship between state spatial regulation, state restructuring, and the competitiveness of city-regions.